Boericke's Materia Medica:
Text: Natural History.
Permanganate of Potassium
Intense irritation of nose, throat, and larynx. Diphtheria. Dysmenorrhoea. Bites of serpents and for other animal poisons. Septic conditions; tissues infiltrated with tendency to sloughing.
Bleeding from nose. Nasal discharge. Smarts and irritates. Constrictive, smarting sensation in throat. Larynx feels raw. Short, hacking cough.
Swollen and painful. Everything hawked up streaked with blood. Posterior nares painful. Muscles of neck feel sore. Swollen uvula. Fetor of breath.
Locally, 1 dram to a quart of water, to correct fetor in cancer, ulcer, ozaena, and other foul odors. Also as an injection in leucorrhoea and gonorrhea. Internally, 2X dilution in water. Saturated solution locally in eruption of small-pox.
Potassium Permanganate for Morphine Poisoning. Potassium Permanganate is recognized as being the most effective chemical antidote in cases of morphine or opium poisoning, acting directly on the morphine and oxidizing it to less toxic substances. To be effective the Permanganate must come in direct contact with the opium or morphine in the stomach; hypodermatic or intravenous injections are absolutely useless, as the salt would be decomposed by the blood serum at once. The approved treatment is administration of two to five grains of potassium Permanganate in dilute aqueous solution as soon as possible after the poison is taken, this amount to be increased if very large doses of the poison have been taken. Washing out the stomach with a quantity of 1 to 500 solution of Permanganate is also recommended, using at least a pint of this solution either by a stomach pump or by enforced vomiting. PERMANG. OF POTASH counteracts effects of alkaloids of many poisonous plants. Owing to its oxidizing powers if given before the alkaloid has been absorbed. (Dr. Chestnut in Dept. of Agriculture.)
Text: Natural History.
Permanganate of Potash. KMnO4.
Solution in distilled water.
Kali-per. is the well-known disinfectant, and has been chiefly used in medicine as a local application in diphtheria and other conditions where there are fetid discharges.
A proving by H. C. Allen has brought out the fact that the medicine is homeopathic to both.
There was intense irritation of nose, throat, and larynx, with sanious and bloody discharges, and constant inclination and constant flow of ropy mucus from the stomach were among the noted effects.
The uvula was swollen and red.
Extreme fetor of the breath and sanious discharges from the nose and intense prostration appear to be the loading indications for it in diphtheria.
(Kraft, who has used it largely in diphtheria, gives it in this way: A few grains are dissolved in a tumbler of water, sufficient to make it very red.
A teaspoonful of this is put into another tumbler of water, and a teaspoonful out of the second tumbler is given every hour or two).
The swollen uvula is also noteworthy.
The exterior of the kali-perm.
He had a wart on the tip of his nose, for which I had given him Thuja internally, and externally in vain, and after this Causticum internally, with no better success.
He on his own account applied a strong solution of Kali-per. in the form of Condy's fluid, and it disappeared in a week.
Compare: Other oxydising salts, especially Kali-bi., also Mang., Caust., Kali-ca., in edematous uvula, Mur-ac., Apis, in diphtheria, Diphth., Mere. cy., Ar. T., Kali-bi., K-m., in thick, ropy mucus, Kali-bi. Kali-per. antidotes Opium. A case of Opium poisoning is reported (H. W., xxxiii. 380), in which recovery took mistake.
Kali an ounce of laudanum had been swallowed by mistake.
Kali-perm. In dilute solution (gr.ii. to the pint) was given repeatedly and acted promptly.
Next day only dryness of mouth and throat was felt.
Head feels full.
Sharp pricking pains extending from throat to left mastoid process, apparently along Eustachian tube.
Nasal discharge smart and irritates.
Sanious discharge, nares feel stuffed and full as in catarrh, discharge blood-streaked, although he had no catarrhal symptoms two hours before.
Discharge from nares and larynx streaked with blood.
Profuse bleeding from nose, on every attempt to free the obstructed nose.
Mouth and lips very dry, lips smart when exposed to cold air.
Profuse flow of saliva, with a burning, raw, smarting, nauseating pain in fauces, pharynx, and larynx, and extending down esophagus to stomach.
Constant inclination to swallow.
Increased flow of saliva runs constantly out of the mouth, with more pain and difficulty of swallowing.
Speech painful, difficult, hoarse as from tonsillitis.
The throat was primarily affected.
Throat swollen and very painful.
Small ulcerated spots here and there on walls of throat, with stinging, burning pains.
Everything hawked up is streaked with blood.
Constant, ineffectual, inclination to hawk something up.
Throat dry, painful, with almost incessant attempts to swallow, from which it is almost impossible to refrain.
Continual dryness in throat, with at slight, irritating, hacking cough on attempting to swallow.
The whole throat and larynx feel as though the cavity was constricted, apparently from thickening of mucous membrane.
Peculiar constrictive, smarting sensation in throat and fauces, with the hot, burning sensation in cardiac end of stomach.
Acute pain in throat, extending to ears and pharynx, and producing a titillating cough.
Throat feels raw, and bleeds on attempting to hawk up the secretions, which appear to fill the cavity.
Posterior nares painful.
Uvula, soft palate, and fauces mottled of a dark red color, with livid sport here and there.
Soft palate and uvula swollen, edematous, dark red.
Fauces and pharynx are and painful, efforts to swallow almost incessant, Profuse flow of saliva which escapes by the mouth on account of the difficulty of swallowing.
Mucous membrane feels thickened.
Burning, nauseating pain in fauces, extending down esophagus to stomach, with dryness and constant inclination to swallow.
Constant, intense, painful inclination to swallow.
Muscles of neck feels sore, especially digastric and stylohyoid, glands opposite hyoid bone swollen and very painful.
Considerable difficulty in opening mouth from soreness of parotid gland and muscles of neck.
Thirst, lout inability to drink.
Almost constant flow of ropy mucus from stomach, which is ejected without pain, but in no way relieves the nausea.
Nausea and constant inclination to swallow.
Could take no more of the drug from a loathing which would almost produce vomiting to look at it, began to search, in vain, for an antidote.
Nausea and vomiting, first of contents of stomach, then thick, ropy fluid, ejected without difficulty in large quantities, with worse of throat pain.
The vomiting, which had ceased last evening, returned in aggravated form, attended with a burning, nauseating pain in stomach and duodenum, which become almost insupportable.
Deep-seated, sickening pain in stomach, with a raw dryness in throat, and constant inclination to swallow.
Hot, burning pain in stomach, seeming to radiate over whole epigastrium.
Hot, burning sensation in cardiac extremity of stomach, with peculiar constricting and smarting sensation in throat, and inclination to swallow, etc., hot, uneasy, constricting sensation through whole length of esophagus, lasted two hours, better by eating.
Compelled to urinate frequently, urine copious, clear, watery.
Urine profuse and watery.
Aching in region of cricoid cartilage, worse every attempt to swallow.
Raw sensation in larynx.
Short, hacking cough, with a constant painful urging to swallow, which causes nausea and inclination to vomit with profuse lachrymation.
Constant short, painful hacking cough, with blood-streaked sputa.
Coughing or even hacking brings up a sanious fluid.
Legs feel as though he could not move them, tremble on attempting to stand.
Terrible weakness and languor, especially of lower limbs, compelled him to lie down.
Restless at night.